Turinabol wikipedia nl

The pharmacodynamics of anabolic steroids are unlike peptide hormones. Water-soluble peptide hormones cannot penetrate the fatty cell membrane and only indirectly affect the nucleus of target cells through their interaction with the cell’s surface receptors . Conversely, as fat-soluble hormones, anabolic steroids are membrane permeable and influence the nucleus of cells by direct action. The pharmacodynamic action of anabolic steroids begin when the exogenous hormone penetrates the membrane of the target cell and binds to an androgen receptor located in the cytoplasm of that cell. From there, the compound hormone-receptor diffuses into the nucleus, where it either alters the expression of genes [ 20 ] or activates processes that send signals to other parts of the cell. [ 21 ] Different types of anabolic steroids bind to the androgen receptor with different affinities , depending on their chemical structure. [ 3 ] Some anabolic steroids such as methandrostenolone bind weakly to this receptor in vitro, but still exhibit androgenic effects in vivo. The reason for this discrepancy is not known. [ 22 ] On the other hand, steroids such as oxandrolone bind tightly to the receptor and act mostly on gene expression . [ citation needed ]

Turinabol wikipedia nl

turinabol wikipedia nl

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turinabol wikipedia nl