Topical nonsteroidal anti-inflammatory drugs the importance of drug delivery and therapeutic outcome

1% Gel:
Lower Extremities: Apply 4 g to the affected foot, knee, or ankle 4 times a day and rub in gently; not to exceed 16 g/day to any single joint of the lower extremities

Upper Extremities: Apply 2 g to the affected hand, wrist, or elbow 4 times a day and rub in gently; not to exceed 8 g/day to any single joint of the upper extremities

Maximum dose: 32 g/day over all affected joints

Comments:
-When used on the lower extremities, this drug should be applied to the entire affected foot, knee, or ankle; the entire foot includes the sole, the top of the foot, and the toes.
-When used on the upper extremities, apply to the entire affected hand, wrist, or elbow; the entire hand includes the palm, the back of the hands, and the fingers.
-The accompanying dosing card should be used for application; consult manufacturer product information for instructions.

Use: For the relief of pain associated with osteoarthritis of the joints amenable to topical treatment, such as the knees and those of the hands; this drug has not been evaluated for use on the spine, hip, or shoulder

% Topical Solution: Apply 40 drops to each affected knee 4 times a day

2% Topical Solution: Apply 40 mg (2 pump actuations) to each affected knee 2 times a day

Use: For the relief of signs and symptoms of osteoarthritis of the knee(s)

Register for alerts
If you have registered for alerts, you should use your registered email address as your username

  • Citation tools Download this article to citation manager Lin Jinying , Zhang Weiya , Jones Adrian , Doherty Michael . Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials BMJ 2004; 329 :324
    • BibTeX (win & mac) Download
    • EndNote (tagged) Download
    • EndNote 8 (xml) Download
    • RefWorks Tagged (win & mac) Download
    • RIS (win only) Download
    • Medlars Download
    Help If you are unable to import citations, please contact technical support for your product directly (links go to external sites):

    Given there’s no long-term data with topical NSAIDs, the evidence doesn’t give us enough insight to understand the risk profile beyond a few weeks. Consequently it seems reasonable to try using topical products instead of oral products, particularly for intermittent, rather than chronic, pain conditions. While compounding pharmacies have made topical versions of NSAIDs for years, there’s little information on effectiveness and safety of these products. As commercial formulations are supported with pharmacokinetic and clinical studies demonstrating efficacy, they are the preparations of choice.

    Что было изучено в этом обзоре?
    Повреждение роговицы это "царапина" на роговице глаза. Роговица - прозрачное окно, располагающееся перед радужкой, цветной частью глаза. Роговица важна как для зрения, так и для защиты глаза. Повреждение роговицы вызывает сильную боль и дискомфорт. Травматическое повреждение роговицы - повреждение роговицы вследствие травмы, например, удара в глаз, или вследствие попадания под веко чего-то вроде грязи или песка, которые царапают роговицу.

    Topical nonsteroidal anti-inflammatory drugs the importance of drug delivery and therapeutic outcome

    topical nonsteroidal anti-inflammatory drugs the importance of drug delivery and therapeutic outcome

    Что было изучено в этом обзоре?
    Повреждение роговицы это "царапина" на роговице глаза. Роговица - прозрачное окно, располагающееся перед радужкой, цветной частью глаза. Роговица важна как для зрения, так и для защиты глаза. Повреждение роговицы вызывает сильную боль и дискомфорт. Травматическое повреждение роговицы - повреждение роговицы вследствие травмы, например, удара в глаз, или вследствие попадания под веко чего-то вроде грязи или песка, которые царапают роговицу.

    Media:

    topical nonsteroidal anti-inflammatory drugs the importance of drug delivery and therapeutic outcometopical nonsteroidal anti-inflammatory drugs the importance of drug delivery and therapeutic outcometopical nonsteroidal anti-inflammatory drugs the importance of drug delivery and therapeutic outcometopical nonsteroidal anti-inflammatory drugs the importance of drug delivery and therapeutic outcometopical nonsteroidal anti-inflammatory drugs the importance of drug delivery and therapeutic outcome