Depending on your personal medical history, you may still be a candidate for premedication. For example, antibiotic prophylaxis might be useful for patients undergoing dental procedures who also have compromised immune systems (due to, for instance, diabetes, rheumatoid arthritis, cancer, chemotherapy, and chronic steroid use), which increases the risk of orthopedic implant infection. It may also benefit others with heart conditions . Always talk with your dentist or physician about whether antibiotic prophylaxis before dental treatment is right for you.
Antibiotics, particularly those in the penicillin and sulfa groups, are the most common cause of drug allergies.  Most drug allergies are usually limited to hives, swelling, and skin rashes, but some people experience rare and life-threatening reactions, called anaphylaxis.  Drug allergies are caused by your immune system mistaking the antibiotic for a foreign substance, inflaming your skin or, in more severe cases, restricting airways and causing shock, which can lead to unconsciousness or death.  If you experience the symptoms of anaphylaxis, it's crucial that you seek medical help immediately, as it is a medical emergency. Learning how to treat skin rashes and recognize the signs of a more severe reaction can help you feel your best, and could save your life.
The first sulfonamide and the first systemically active antibacterial drug, Prontosil , was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany,    for which Domagk received the 1939 Nobel Prize in Physiology or Medicine.  Sulfanilamide, the active drug of Prontosil, was not patentable as it had already been in use in the dye industry for some years.  Prontosil had a relatively broad effect against Gram-positive cocci , but not against enterobacteria . Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials.