Banamine as well as a number of other drugs (ivermectin, progesterone, anti-histamines, phenylbutazone, dipyrone, vitamin B complex, synthetic prostaglandins) can cause muscle damage when injected. While this usually causes few problems, spores of the bacteria Clostridium can lie dormant in healthy muscle and begin to proliferate if muscle is damaged. Growth of this bacteria causes Clostridial myositis, a serious and sometimes fatal condition. Within 6 to 72 hours of the bacterial infection beginning, horses develop swelling and crunchy areas of gas under the skin at the site of the IM injection. As bacterial toxins are released into the bloodstream horses quickly become very ill with signs of depression, colic, purple gums, and reluctance to move. Diagnosis of Clostridial myositis is made by identifying gas produced by Clostridia in the damaged muscle using ultrasound and by examining aspirates of the area for bacteria.