Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs

Once a drug’s bioavailability has been established it is possible to calculate the changes that need to be made to its dosage in order to reach the required blood plasma levels. Bioavailability is therefore a mathematical factor for each individual drug that influences the administered dose. It is possible to calculate the amount of a drug in the blood plasma that has a real potential to bring about its effect using the formula: D e = B ⋅ D a {\displaystyle De=B\cdot Da\,} ; where De is the effective dose , B bioavailability and Da the administered dose.

Effects of PON1 Gene Promoter DNA Methylation and Genetic Variations on the Clinical Outcomes of Dual Antiplatelet Therapy for Patients  Undergoing Percutaneous Coronary Intervention
This study included 653 patients with CAD undergoing PCI and receiving dual antiplatelet therapy. Genomic DNAs were isolated from whole blood and were genotyped for the three single nucleotide polymorphisms (SNPs) of thePON1 gene. The DNA methylation levels in thePON1 promoter region were determined by bisulfite sequencing or pyrosequencing at five CpG sites (positions −142, −161, −163, −170, and −184 from the transcription start site). Clopidogrel and its metabolites in plasma were examined using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), and platelet f...
Source: Clinical Pharmacokinetics - September 5, 2017 Category: Drugs & Pharmacology Source Type: research

Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.

Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs

clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs

Media:

clinical pharmacokinetics of nonsteroidal anti-inflammatory drugsclinical pharmacokinetics of nonsteroidal anti-inflammatory drugsclinical pharmacokinetics of nonsteroidal anti-inflammatory drugsclinical pharmacokinetics of nonsteroidal anti-inflammatory drugsclinical pharmacokinetics of nonsteroidal anti-inflammatory drugs