One hour after HC administration, significantly increased plasma cortisol levels were noted in patients taking high-dose HC compared with those taking low-dose HC (median 741 nmol/L; interquartile range [IQR]: 669-870 vs median 499 nmol/L; IQR: 363-605; P <.001). Similar differences were noted 5 hours after the morning HC dose (median: 235 nmol/L; IQR: 170-314 and median: 112 nmol/L; IQR: 75-199; for higher and lower doses, respectively; P <.001). However, no z-score differences were recorded in any somatosensory functioning measures, and rates of sensory abnormality did not differ between patients taking lower or higher doses of HC (27%; 95% CI, 14%-40% vs 29%; 95% CI, 16%-24%, respectively).
Causes of primary adrenal insufficiency (Addison's disease)
Causes of secondary and tertiary adrenal insufficiency in adults
Clinical manifestations of adrenal insufficiency in adults
Diagnosis of adrenal insufficiency in adults
Evaluation of the response to ACTH in adrenal insufficiency
Hyponatremia and hyperkalemia in adrenal insufficiency
Pathogenesis of autoimmune adrenal insufficiency
Treatment of adrenal insufficiency in adults
Treatment of adrenal insufficiency in children
The . Food and Drug Administration (the government agency that oversees most food and medical products) does not oversee nutritional supplements and vitamins. This means there is no guarantee that what's on the label of a supplement is really what's inside the bottle. In some cases, supplements have very few, if any, active ingredients. In other cases, the dose of a particular ingredient may be too high. This is true if you purchase supplements from your local drug store or a specialty pharmacy (sometimes called a compounding pharmacy) where supplements are made directly by the pharmacist.